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Pilot studies have indicated that single-cell omics (scOmics) approaches play an important role in studying the function of cells and revealing the difference between individual cells. Single-cell technologies can analyze the cell at different levels, including the genome, transcriptome, epigenome, as well as proteome. The results have been considered as critical data for analyzing disease biology and predicting the efficacy of novel drugs or therapies. With the extensive experiences and advanced platforms, SingleX has developed a wide variety of single-cell omics services to identify the role of immunity and microbiome in disease treatments, especially for cancer therapy.

Single Cell Omics Solutions for Tumor Infiltrated Immune Cells

Tumor-infiltrating immune cells have been regarded as attractive markers for revealing the immune responses and tumor control in various cancer immunotherapy. scOmics technologies have been widely used for analyzing the heterogeneity of cells and molecules in the tumor microenvironment (TME). Meanwhile, scOmics analysis of tumor-infiltrating immune cells is also critical to determine the cell interactions in cancer research. SingleX now offers a collection of single-cell omics services for quantifying different cell types, such as T cells, B cells, dendritic cells (DCs), natural killer cells (NKs), macrophages, myeloid-derived suppressor cells (MDSCs), as well as neutrophils. The molecular mechanisms and the phenotypes of various tumor-infiltrating immune cells can provide further information on revealing cellular interactions, predicting the results of different therapeutic interventions, and studying tumor development and treatment.

Tumor infiltrated immune cells. Fig.1 Tumor infiltrated immune cells. (Kerkar, 2012)

Single Cell Omics Solutions for Human Microbiome

The human microbiome has possessed rich resources for a number of functional genomic studies and different cancer therapies. In order to obtain a deep understanding of the genotypes and phenotypes of the human microbiome, scOmics strategies have been widely developed for studying their functions and biological activities at single-cell levels. Currently, SingleX has established a comprehensive scOmics solutions to help the sequencing and analysis of the human microbiome, which usually needs to perform a series of assays, at the level of genomics, transcriptomics, epigenomics, and proteomics. Among them, single-cell sequencing of microbial genomes is a common method for understanding the cell structures for cancer immunotherapy.

Overview of steps for single-cell sequencing of microbial genomes. Fig.2 Overview of steps for single-cell sequencing of microbial genomes. (Tolonen, 2017)

Advantages of Our Single Cell Omics Solutions for Immunity and Microbiome

  • A variety of approaches to study the behavior, mechanism, and relationship of individual cells
  • Excellent expert team for offering real-time technical guidance
  • Stable, batch analysis of single-cell data
  • Timely data feedback to facilitate the process of your project

Compared to traditional bulk cell omics research, single-cell omics research can not only detect accurate gene expression and mutation at the single-cell level but also detect rare cells. The advantages are omnidirectional and multi-layered. SingleX has the most comprehensive strategies and platforms to provide you with single cell omics solutions for immunity and microbiome. If you want to know more details, please contact us for assistance.

References

  1. Tolonen, A. C., et al. Dissecting the human microbiome with single-cell genomics. Genome Med. 2017, 9(1): 56.
  2. Kerkar, Sid P., and Nicholas P. Restifo. "Cellular constituents of immune escape within the tumor microenvironment." Cancer research 72.13 (2012): 3125-3130.

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